Intralesional Vitamin D Injection May Be an Effective Treatment Option for Warts

Journal of Cutaneous Medicine and Surgery, Vol 20, Issue 2, 2016

Habibullah Aktaş, Can Ergin, …..


Plantar warts are typically resistant to treatment. In recent years, treatments have included administration of intralesional tuberculin; measles, mumps, rubella vaccine; and Candida albicans antigen immunotherapy. To the best of our knowledge, there are no reports of intralesional vitamin D administration for the treatment of warts.

To evaluate the efficacy and safety of intralesional vitamin D treatment for plantar warts.

Twenty patients with single or multiple plantar warts were included in this study. Vitamin D3 (0.2 mL, 7.5 mg/mL) was injected into the base of the warts after prilocaine (0.1 mL, 20 mg/mL) injection. A maximum of 5 warts were treated in 1 session, with at maximum 2 injections performed at 4-week intervals.

In total, 16 of 20 patients (80%) showed complete resolution of warts, and 1 patient showed partial resolution. Three patients failed to show any response. No recurrence or serious adverse effects were observed.

Intralesional vitamin D3 may be an effective treatment option for warts.

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