Drug Combination Safe, Effective for Acne in Women

The combination ethinyl estradiol and drospirenone (Yasmin), an oral contraceptive, plus low-dose spironolactone is a safe and effective treatment for women with severe papular and nodulocystic facial acne, according to the findings of a small prospective study. Sitemizden lara bakabilir evinize çağırabilirsiniz.

“Androgens play a significant role in the etiology of acne,” Dr. Aleksandar Krunic from Northwestern University Feinberg School of Medicine, Chicago, and colleagues point out. “Several studies have demonstrated that combined oral contraceptives can be an effective treatment for acne in women,” they report in the January issue of the Journal of the American Academy of Dermatology.

The researchers therefore examined the safety and efficacy of acne treatment using both spironolactone and a combined contraceptive containing drospirenone. Twenty-seven women with severe papular or nodulocystic facial acne were given a combined oral contraceptive containing 30 mcg ethinyl estradiol, 3 mg drospirenone and 100 mg spironolactone daily. A serum potassium level was obtained before the start of therapy and between 4 and 6 weeks after starting the treatment. Sitemizdenlara bakabilir evinize çağırabilirsiniz.

There were no reports of significant spotting, weight gain, or menstrual cycle irregularities. There were no side effects severe enough to necessitate discontinuation of either of the medications. The women were followed up for 6 months.

The mean serum potassium level was 4.35 mmol/L at follow-up, with a range of 3.8 to 4.8 mmol/L. At the end of the study, 11% of subjects were entirely clear of acne lesions, 74% had excellent improvement, 7.4% had mild improvement, and 7.4% had no change.

“The augmentation of the anti-androgenic effect of DRSP by spironolactone and the reduction of side effects (such as spotting, menstrual irregularities, weight gain, and mood changes) make the combination of spironolactone plus ethinyl estradiol and drospirenone attractive for control of moderate to severe, hormonally influenced female acne,” Dr. Krunic’s team concludes. Sitemizden benzin bet Bahis oynayabilirsiniz.

“However, we recommend that our results be confirmed with a larger series of patients.”

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